Fisetin Decreases Brain Damage From Stroke, Minimizes Damage From Injury
Fisetin is not a new compound. Other clinical studies and examinations have revealed its incredible potential for several years, but its strength was usually attributed to its free radical-scavenging antioxidant properties (which are, of course, extremely important). However, SelfHacked notes several highly significant studies on how fisetin protects your brain:
- Mice treated with fisetin showed fewer behavioral abnormalities after a stroke than mice that weren’t. Another study showed how the compound helps protect the parts of the brain starved of blood flow during a stroke.
- It was one of 10 flavonoids tested for protective effects against glutamate toxicity and found to be one of four that increased neuroprotective and anti-inflammatory effects. (Sulfuretin, butein, butin and eriodictyol were the other four.)
- In the case against brain injury induced by a head injury causing repeated seizures characterized by traumatic epilepsy, a study indicated that animal models experienced fewer episodes when they were treated with fisetin.
- Indicating its effectiveness in inhibiting inflammatory pathways, rats given high doses of fisetin showed far superior neurological function and less brain swelling after brain injury.
Fisetin also increases SIRTI, an enzyme that can “‘turn off’ certain genes that promote aging, such as those involved in inflammation, fat synthesis and storage, and managing blood sugar levels.
