Neuroprotective Aspects of Fisetin
Aluminum chloride, a neurotoxin, is a common ingredient in one of the products many Americans say they would never go without: antiperspirants. But fisetin has been shown to protect against the damaging effects of this common household ingredient. Fisetin was shown to lower elevated levels of ammonia in blood (hyperammonemia) with the potential to damage vital brain functions in hyperammonemic rats.
Another brain protective aspect of fisetin, shown in mice, is its power to increase serotonin, which helps elevate your mood and energy, and noradrenaline, a hormone produced naturally by the body that functions as a neurotransmitter. One study explains the importance of noradrenaline “to maintain the cognitive processes such as attention, perception, and particularly the memory consolidation and retrieval. Disruption of these processes may result in symptoms of neuropsychiatric diseases and neurodegeneration.”
Mice given fisetin in another study revealed fewer symptoms of anxiety and depression brought on by pain. Further, the antidepressant effects of fisetin are shown to be enhanced by 5-Hydroxytryptophan (5-HTP), an amino acid precursor of serotonin, with additional benefits for anti-anxiety, sleep and weight loss, SelfHacked explains.
